This has been discussed before in great detail; even Chemsynth got involved. We never reached a conclusion. Potentially there are interactions between Tramadol and SSRIs/SNRIs, but so many people are on these drugs, who also have pain, and there are so many doctors who want to give Tramadol instead of traditional opioids, that many patients have no choice.

Also there are quite a few people on this board who take the 2 drugs together and don't experience problems.

Bertinetti was commenting on clonazepam because it raises the seizure threshold.

Serotonin syndrome is the main concern, and patients on these drugs ought to look out for the signs of this.

Thank you so much! This is hard...I ended up only taking the one last night but i had to take another 1mg xanax to go to sleep. Then i only slept for an hour and woke up with restless leg, that lasted for hours before i went and took some nyquil, i had to go to sleep. it was a bad night to say the least. not much better this morning either, have not taken anything today..yet. I welcome any advise.

Tramadol could work for migraines. Although, meds that are made to specifically target migraines would be more along the lines of what you need. I take Tramadol for joint pain. Tramadol has been a success story for me. I am unable to take stronger pain medications due to the fact that taking them nauseates me.
Ultram is the name brand of tramadol hydrochloride. Ultracet is simply tramadol with tylenol. I would recommend the generic because it is exactly the same thing as the brand. I would probably stay clear of Ultracet because taking more tylenol than one needs is not necessary (IMO). I'm not a doctor, but I think that tramadol is easier on the liver than OTC pain relievers.

Thanks for the info. Traditional migraine meds don't work for me. I have a friend that gets 50 or more botox injections to her scalp -- all in one sitting -- because nothing works for her migraines, and even that is not working right now. I just can't go there.

Anyway, I digress. I see that Tramadol cannot be taken with Wellbutrin and other antidepressants. Does that include Prozac? I take both. So if I need to take Tramadol but have already taken my anti D's that day, don't take it. But if I haven't taken them yet that day is it safe? Or do you have to be off them for a period of time before taking Tramadol? I will also ask PCP next time I see him but just wondered if anyone knows the answer to that question.

Thanks!

No, the pain relief will not increase. Tramadol works also as an SNRI (Effexor is a pure SNRI) but Tramadol also works by mocking how true opiates bind to the Mu rector. So just be careful with the SNRI action and properties it has. I personally have about 4 years of experience and daily taking of Tramadol, I know everything there is know from learning, research, and most of all personal experiences. If anyone has any further questions feel free to ask, there is a lot of rumors and invalid myths and info going around about Tramadol.

The parenteral route allows for greater daily doses than does PO; does this mean that SL, buccal and PR total daily doses can be higher in the same proportion?

Some here know my medical history so im not going to go through it again in full, quick summary though, I had avascular necrosis in my hips, had bilateral coredecompression, left sorted, no problems, right still giving problems. Have been on Trams daily since last year Novemberish. I know about the 400 mg rule but hand on heart have taken up to 16 50mg in a day at times along with quite a few co-codomols and have never had any noticeable probs. (this was purely to get through work, I dont find they give me any sort of high, never have)
I have been much better but had to do a lot of running around during my sons birth this week (had my op about 12 weeks ago) so had a flare up of pain, I took quite a few trams yesterday and today and have had the usual persistent problem I have when taking too many, problem urinating, I am also having kidney pains on the left side. I really want to try something different but the docs will just not prescribe me anything else, and thats after changing docs twice!!

I also take Valium/Xanax (depending on the day) and Modalert and ephedrine when working nights.

Is there anything that will be less damaging and more effective for the pain when it does flare up. I am in all honesty battling to get off the Trams now, I find I get sweats and irritabillity so take one or two a day on the good days, its getting ridiculous.

Ive tried Bupe 0.2 x 2 and they seem to work, would these be any less damaging or difficult to get off while I work through the last stage of this problem.

Im also worried about my liver and kidneys, I gave up drinking and smoking in March so obviously that has helped, any suggestions on something to help protect the liver and kidney, and most of all the urination problems, is that something to worry about long term, it really causes me concern.

Any advice would be greatly appreciated.


Originally Posted By: ProAnthGonz
No, the pain relief will not increase. Tramadol works also as an SNRI (Effexor is a pure SNRI) but Tramadol also works by mocking how true opiates bind to the Mu rector. So just be careful with the SNRI action and properties it has. I personally have about 4 years of experience and daily taking of Tramadol, I know everything there is know from learning, research, and most of all personal experiences. If anyone has any further questions feel free to ask, there is a lot of rumors and invalid myths and info going around about Tramadol.